Upon completing Module 5, students will be able to:

• Understand the fundamental principles of biomarker discovery and validation in liver disease.
• Critically evaluate the performance characteristics of diagnostic biomarkers, including sensitivity, specificity, and predictive values.
• Apply current knowledge on the use of biomarkers for risk stratification and prognostic modeling in acute-on-chronic liver failure (ACLF) and decompensated cirrhosis.
• Interpret diagnostic accuracy studies and understand their role in clinical decision-making and personalized medicine.
• Assess regulatory and methodological considerations in biomarker research and implementation in clinical practice.

The content for this module has been developed jointly by Aleksander Krag and Nikolaj Torp from University of Southern Denmark and Odense University Hospital, Denmark.